ABSTRACT
Objective To study the change of diastolic cardiac function in diabetic patients and to determine the diagnostic value of plasma brain natriuretic peptide (BNP) and atria natriuretic peptide (ANP) for diastolic heart failure in patients with type 2 diabetes mellitus.Methods Twelve healthy subjects and seventy-one diabetic patients were included in the study.Plasma BNP and ANP were measured with immunoradiometic assay.Results Plasma levels ofBNP andANP increased significantly with increased severity of diastolic heart dysfunction.The ratio of E/A had significant negative correlation with the plasma levels of BNP (r=0.669,P＜0.001) and ANP (r=0.579,P＜0.01).AUC of ANP and BNP in ROC model was 91.9% and 65.3%,respectively.Conclusions The plasma level of BNP might be a valuable predictor for differential diagnosis of diastolic cardiac function in diabetic patients.
ABSTRACT
Objective: To determine the diagnostic value of the concentration of plasma BNP and ANP in patients of type 2 diabetes mellitus with diastolic heart failure(DHF). Methods:12 healthy subjects and 71 diabetic patients were selected into the study. Left ventricular ejection fraction(LVEF) ,mitral annular early diastole (E) and late diastole (A) inflow velocities were measured with Doppler echocardiography .According to the result of ratio of E to A, the DHF patients were subdivided into DHF 1 group:0.8 ≤ E/A
ABSTRACT
<p><b>OBJECTIVE</b>To detect free testosterone (FT) in the serum and semen of patients with idiopathic oligospermia, and further analyze the relationship between FT and idiopathic oligospermia.</p><p><b>METHODS</b>Blood samples were collected from the males of a normal control group (n = 44) and an idiopathic oligospermia group (n = 44) at 8:00-10:00 a.m.. Semen samples were collected from the males of a normal control group (n = 30) and an idiopathic oligospermia group (n = 37) at the same time. Sperm density was detected by routine semen analysis, and FT in the serum and semen was detected by RIA.</p><p><b>RESULTS</b>There was no significant difference in the serum concentrations of FT between the groups of normal control [(97.50 +/- 46.96) pmol/L] and idiopathic oligospermia [(94.88 +/- 42.04) pmol/L], P > 0.5. But the difference was significant in the semen concentrations of FT between the groups of normal control [(2.01 +/- 0.32) pmol/L] and idiopathic oligospermia [(0.52 +/- 0.44) pmol/L], P < 0.01.</p><p><b>CONCLUSION</b>Measurement of semen FT concentration could early reflect the function of the testis, which contributes to the early diagnosis and treatment of idiopathic oligospermia.</p>
Subject(s)
Adult , Humans , Male , Middle Aged , Case-Control Studies , Oligospermia , Blood , Metabolism , Semen , Chemistry , Testosterone , Blood , MetabolismABSTRACT
Objective:To study the alteration of cardiac function in diabetic patients and evaluate the relationship between cardiac function and BNP. Methods:83 diabetic patients and 12 healthy subjects were selected into the study. Left ventricular ejection fraction(LVEF) and mitral annular early diastole (E) and late diastole (A) inflow velocities were measured with echocardiography. Plasma BNP were measured with Immnoradiometic assay(IRMA)? Results:According to the result of the echocardiography, the diabetics who have no primary cardiac diseases were subdivided into normal cardiac function group( n =24,28.9%),diastolic dysfunction group( n =47,56.7%), systolic dysfunction group( n =6,7.2%), both diastolic and systolic dysfunction group( n =6,7.2%). More than half of diabetic patients have diastolic dysfunction. The plasma level of BNP had significant negative correlation with LVEF( r = -0.614, P
ABSTRACT
100 U/L were higher than those in group of CK-MB≤100 U/L(P
ABSTRACT
Twelve healthysubjects and 71 diabetic patients, including 47 cases with diastolic heart failure (DHF), were enrolled into the study. Plasma atrial natiuretic peptide (ANP) and brain natriuretic peptide (BNP) were measured with immunoradiometric assay. The result showed that the plasma levels of ANP and BNP were significantly increased in accordance withthe severity of DHF. The ratio of E/A had significantly negative correlation with the plasma levels of BNP(r=-0.669,P
ABSTRACT
The expression of human epidermal growth factor (hEGF) and hEGF receptor (hEGF-R) was examined by 125I-labeled-hEGF binding analysis in 21 cases of colonic carcinomas. No significant difference was found in the values of hEGF binding among carcinoma, paracarcino-ma regions and regions far away from carcinoma, but the values in all of them were higher than that in normal colonic tissues (P